Orlando is known as "the theme park capital of the world" where it hosts Disney World (with Epcot Center) and others. Being in the state of Florida there is usually a lot of sun and playing golf is a serious option.
Everglades National Park is a large network of wetlands and forests in Southern Florida with animal life like panther, crocodile and manatee. The park is the largest tropical wilderness in the United States and a World Heritage Site.
Miami Florida is one of the main economic centres of the USA. It also has a world-famous beach and the best weather. Cuban and Puerto Rican influence is felt here, for example Miami Sound Machine. For many this is the starting point of a great US vacation.
New York City has a few nick names, for example "The Big Apple", "The City That Never Sleeps" and "The Financial Capital of the World". We cannot list everything that there is to do in NYC, because it is too much. The basics however are the Statue of Liberty, Times Square, Broadway, Little Italy / China Town and the Empire State Building.
San Francisco is a favourite city for so many: Americans, Tourists and Homeless. The climate is just perfect for almost anything including growing wine (Napa valley) or computer (Silicon Valley). Tourist will enjoy the local cable train, Alcatraz prison and The Golden Gate bridge.
Charleston (South Carolina) has a long history that is reflected in the colonial buildings. Long it has been one of the major cities in the USA. Nowadays it is a real pleasant city.
Memphis is home for music legends Johnny Cash and Elvis Presley. Graceland, home and final resting place of the King of Rock and Roll, can be found here.
Nashville is the second largest city in Tenessee and the heart of Country Music. Of course you should listen to the music that inspired so many and visit The Country Music Hall of Fame.